Near Saint Francis Medical Center
When you stay at Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel in Cape Girardeau, you'll be near the airport, within a 10-minute drive of Shawnee National Forest and Mississippi River. This spa hotel is 0.5 mi (0.8 km) from Saint Francis Medical Center and 2.3 mi (3.7 km) from Saint Francis Healthcare System.
Make yourself at home in one of the 102 guestrooms featuring microwaves and flat-screen televisions. Your pillowtop bed comes with down comforters and premium bedding. Complimentary wired and wireless internet access keeps you connected, and cable programming provides entertainment. Private bathrooms have complimentary toiletries and hair dryers.
Take time to pamper yourself with a visit to the full-service spa. If you're looking for recreational opportunities, you'll find an indoor pool and a fitness center. Additional features at this hotel include complimentary wireless internet access, a banquet hall, and a vending machine.
Featured amenities include complimentary wired internet access, a business center, and complimentary newspapers in the lobby. Planning an event in Cape Girardeau? This hotel has 118 square feet (11 square meters) of space consisting of conference space and a meeting room. Free self parking is available onsite.
English
Top Location: Highly rated by recent guests (9.4)
Want a great night's sleep? This property was highly rated for its very comfy beds.
Free Private Parking Available On Site
Free self parking
There are more repeat guests here than most other properties.
Most popular facilities
Gym
Spa
Business services
Laundry
Breakfast available
24/7 front desk
Pool
Free wifi
Parking
Housekeeping
Suite, 1 King Bed
sq ft Free wifi Free self parking Sleeps 2 1 King BedMore detailsSuite, 2 Queen Beds
sq ft Free wifi Free self parking Sleeps 6 2 Queen BedsMore detailsSuite, 2 Queen Beds, Accessible (Mobility)
400 sq ft Free wifi Free self parking Sleeps 6 2 Queen BedsMore detailsStandard Room, 1 Queen Bed
400 sq ft Free wifi Free self parking Sleeps 2 1 Queen BedMore detailsStandard Room
400 sq ft Free wifi Free self parking Sleeps 2 1 King BedMore detailsSuite, 1 Bedroom (Feature)
sq ft Free wifi Free self parking Sleeps 2 1 Queen BedMore detailsSuite, 1 King Bed, Accessible (Mobility)
sq ft Free wifi Free self parking Sleeps 2 1 King BedMore detailsSuite, 2 Queen Beds, Accessible (Roll-In Shower)
400 sq ft Free wifi Free self parking Sleeps 6 2 Queen BedsMore detailsSuite, 1 King Bed, Accessible (Roll-In Shower)
sq ft Free wifi Free self parking Sleeps 2 1 King BedMore detailsWonderful · 1,001 reviews
Cleanliness
9.4/10
Location
7.4/10
Recommendation
92.3%
Closest airports
Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
9.8 km / 6.1 mi
Cairo, IL (CIR-Cairo Regional)
50.6 km / 31.4 mi
What's nearby
Saint Francis Medical Center
0.9 km / 0.6 mi
Southeast Missouri Hospital
4.1 km / 2.6 mi
Saint Francis Healthcare System
4.2 km / 2.6 mi
Southeast Missouri State University
4.8 km / 3 mi
Cape Splash Family Aquatic Center
4.8 km / 3 mi
EDen Spa & Salon
5.2 km / 3.2 mi
Riverfront Bridge Park
5.5 km / 3.4 mi
Riverfront Park
5.6 km / 3.5 mi
Fort D Historic Site
6.5 km / 4.1 mi
Isle Casino Cape Girardeau
6.6 km / 4.1 mi
Shawnee National Forest
6.7 km / 4.2 mi
Show Me Center
6.7 km / 4.2 mi
Cape Girardeau Conservation Nature Center
6.9 km / 4.3 mi
Mississippi River
7.2 km / 4.5 mi
Cape Rock Park
10.1 km / 6.3 mi
Most Popular Amenities
Gym
Spa
Business services
Laundry
Breakfast available
24/7 front desk
Pool
Free wifi
Parking
Housekeeping
Air conditioning
Top family-friendly amenities
Parking and transportation
Wheelchair accessible parking
Free self parking
Internet
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Restaurants on site
Pool sun loungers
Activities nearby
Free self parking
Things to do
Fitness facilities
Swimming pool
Television
Family friendly
Laundry facilities
Conveniences
Safe-deposit box at front desk
24-hour front desk
Luggage storage
In-room safe
Guest services
Laundry facilities
Porter/bellhop
Dry cleaning/laundry service
Daily housekeeping
Business services
Conference space
Business center
Conference space size (feet) - 118
Conference space size (meters) - 11
Number of meeting rooms - 1
Outdoors
Swimming pool
Number of indoor pools - 1
Pool sun loungers
Full-service spa
Conference space
Free newspapers in lobby
Full-service spa
Conference space size (feet) - 118
Conference space size (meters) - 11
Health or beauty spa nearby
Laptop-friendly workspace
Languages spoken
English
If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
Common areas
Internet access in public areas - high speed
Wheelchair accessible path of travel
Wheelchair accessible parking
Wheelchair accessible (may have limitations)
Wheelchair-accessible path to elevator
Dial-up internet access
High-speed internet access
Wireless internet access
Internet access (complimentary)
Wheelchair accessible
Check-in
From 3:00 PM
Guests are required to show a photo ID and credit card at check-in.
Check-out
Until 11:00 AM
Cancellation/ prepayment
Cancellation and prepayment policies vary according to accommodation type.Enter your stay dates and check the conditions of your selected option.
General Instructions
Front desk staff will greet guests on arrival at the property.
Age restriction
The minimum age for check-in is 21
Cards accepted at this property
We should mention
92% of our clients have rated us with 5 stars





Flight inclusive holiday packages and Flight Plus Holidays (as defined in our Terms of Business) on this website are financially protected by the ATOL scheme. The ATOL protection does not apply to all holiday and travel services listed on this website. Please ask us to confirm what protection may apply to your booking. If you do not receive an ATOL certificate then the booking will not be ATOL protected. If you do receive an ATOL Certificate but all the parts of your trip are not listed on it, those parts will not be ATOL protected.
Please see our Terms of Business for information, or for more information about financial protection and the ATOL Certificate go to: http://www.atol.org.uk .
© 2026 iTravel Holidays | All rights reserved.